GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs3136441 | 1 | rs4752940 | chr11:46847715 | DDB2 | chr11:47236493-47260769:+ | 0.22 | 3.53 | 0.000459 | HDL cholesterol |
| THCA | cis | rs3136441 | 1 | rs4752940 | chr11:46847715 | ZNF408 | chr11:46722368-46727461:+ | -0.18 | -3.52 | 0.000472 | HDL cholesterol |
| THCA | cis | rs3136441 | 1 | rs4752946 | chr11:46896908 | DDB2 | chr11:47236493-47260769:+ | 0.21 | 3.47 | 0.000561 | HDL cholesterol |
| THCA | cis | rs3136441 | 1 | rs4752947 | chr11:46901156 | DDB2 | chr11:47236493-47260769:+ | 0.22 | 3.47 | 0.000574 | HDL cholesterol |
| THCA | cis | rs3136441 | 1 | rs4752947 | chr11:46901156 | ZNF408 | chr11:46722368-46727461:+ | -0.19 | -3.61 | 0.000335 | HDL cholesterol |
| THCA | cis | rs4237643 | 1 | rs4755726 | chr11:43642130 | HSD17B12 | chr11:43702143-43878160:+ | -0.68 | -14.09 | 6.08E-38 | Forced vital capacity |
| THCA | cis | rs10128711 | 1 | rs4757676 | chr11:18640477 | SPTY2D1 | chr11:18627949-18656020:- | -0.14 | -4.64 | 4.5E-6 | Cholesterol, total |
| THCA | cis | rs4759042 | 1 | rs4759042 | chr12:57377347 | STAT6 | chr12:57489195-57522883:- | 0.16 | 3.86 | 0.000129 | Migraine |
| THCA | cis | rs4759042 | 1 | rs4759042 | chr12:57377347 | TMEM194A | chr12:57449427-57472574:- | 0.16 | 3.85 | 0.000135 | Migraine |
| THCA | cis | rs877636 | 1 | rs4759229 | chr12:56474480 | RAB5B | chr12:56367760-56388478:+ | -0.24 | -4.3 | 2.06E-5 | Cognitive function |
| THCA | cis | rs877636 | 1 | rs4759229 | chr12:56474480 | RPS26 | chr12:56435686-56438005:+ | -0.7 | -13.48 | 2.52E-35 | Cognitive function |
| THCA | cis | rs736825 | 1 | rs4759318 | chr12:54420098 | SMUG1 | chr12:54573783-54582757:- | -0.1 | -3.35 | 0.000864 | Bone mineral density |
| THCA | cis | rs4759375 | 1 | rs4759375 | chr12:123796238 | C12orf65 | chr12:123717841-123742481:+ | -0.25 | -3.91 | 0.000106 | HDL cholesterol |
| THCA | cis | rs4759375 | 1 | rs4759377 | chr12:123796849 | C12orf65 | chr12:123717841-123742481:+ | -0.24 | -4.1 | 4.9E-5 | HDL cholesterol |
| THCA | cis | rs7301826 | 1 | rs4759787 | chr12:131290180 | STX2 | chr12:131274149-131323811:- | -0.67 | -10.17 | 4.07E-22 | Plasma plasminogen activator levels |